Hydrochloric Acid → 4-[(Benzylamino)methyl]benzonitrile

HRID 1941099노트

반응식

HRID 1941099 반응식
C([C:8](=[N:17]O)[C:9]1[CH:16]=[CH:15][C:12]([C:13]#[N:14])=[CH:11][CH:10]=1)C1C=CC=CC=1.Cl>C(O)C>[CH2:8]([NH:17][CH2:8][C:9]1[CH:10]=[CH:11][C:12]([C:13]#[N:14])=[CH:15][CH:16]=1)[C:9]1[CH:16]=[CH:15][CH:12]=[CH:11][CH:10]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 86751769HCID 86751769, 화합물

생성물 1

HCID 123291374-[(Benzylamino)methyl]benzonitrile

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

3.44 g (15 mmol) of 4-(benzyloximinomethyl)benzonitrile in 120 ml of ethanol are cooled to -15° C. 4.46 g (48 mmol, 4.85 ml) of borane-pyridine complex are then added dropwise in the course of 10 minutes and then 26 ml of ethanolic HCl solution in the course of 20 minutes. After stirring at room temperature for 24 h, the resulting solid is filtered off, dissolved in dichloromethane and the solution is washed with water and sodium hydrogen carbonate solution. The organic phase is dried and concentrated in vacuo.

후처리

  1. addition4.46 g (48 mmol, 4.85 ml) of borane-pyridine complex are then added dropwise in the course of 10 minutes
  2. customin the course of 20 minutes
  3. filtrationthe resulting solid is filtered off
  4. dissolutiondissolved in dichloromethane
  5. washthe solution is washed with water and sodium hydrogen carbonate solution
  6. customThe organic phase is dried
  7. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-bb0550b839ee43c0a9551859d23e1f80
출처 데이터셋
uspto-grants-1997_12
특허 번호
US05703050

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