Trichloroacetyl chloride → 2,2,2-Trichloro-1-morpholin-4-ylethanone
반응식
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.C([O-])([O-])=O.[K+].[K+].[Cl:13][C:14]([Cl:19])([Cl:18])[C:15](Cl)=[O:16]>CCOC(C)=O>[Cl:13][C:14]([Cl:19])([Cl:18])[C:15]([N:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1)=[O:16]참가 물질
5
실험 절차
Morpholine (4.0 mL, 45 mmol) is dissolved in EtOAc (50 mL) and saturated K2CO3 (40 mL) added. The mixture is cooled in an ice bath and trichloroacetyl chloride (5.0 mL, 45 mmol) added drop-wise. The reaction is stirred for 20 min then diluted with EtOAc (200 mL) and washed with aq. K2CO3 (20 mL), water (2×50 mL) and brine (30 mL). The organic layer is dried over MgSO4. Rotary evaporation gives trichloroacetylmorpholine.
후처리
- temperatureThe mixture is cooled in an ice bath
- washwashed with aq. K2CO3 (20 mL), water (2×50 mL) and brine (30 mL)
- dry with materialThe organic layer is dried over MgSO4
- customRotary evaporation
출처 및 근거
- ORD 기록
- ord-5b24642c9cda4212a92327a9f47a5809
- 출처 데이터셋
- uspto-grants-1997_12
- 특허 번호
- US05703075
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