N-(3-Methoxy-propyl)-C-(3-nitro-phenyl)-methanesulfonamide → C-(3-amino-phenyl)-N-(3-methoxy-propyl)-methanesulfonamide

HRID 1941912노트

반응식

HRID 1941912 반응식
[CH3:1][O:2][CH2:3][CH2:4][CH2:5][NH:6][S:7]([CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([N+:17]([O-])=O)[CH:12]=1)(=[O:9])=[O:8]>[Ni].CO>[NH2:17][C:13]1[CH:12]=[C:11]([CH2:10][S:7]([NH:6][CH2:5][CH2:4][CH2:3][O:2][CH3:1])(=[O:9])=[O:8])[CH:16]=[CH:15][CH:14]=1

참가 물질

4

반응물 1

HCID 59411197N-(3-Methoxy-propyl)-C-(3-nitro-phenyl)-methanesulfonamide

생성물 1

HCID 43256757C-(3-amino-phenyl)-N-(3-methoxy-propyl)-methanesulfonamide수율 50.2%

시약·촉매·용매 2

HCID 935Nickel촉매HCID 887Methanol용매

실험 절차

N-(3-Methoxy-propyl)-C-(3-nitro-phenyl)-methanesulfonamide (0.31 g, 1.08 mmol) was hydrogenated over Raney nickel (0.05 g) in methanol at 50° C. and 70 psi for 4 h. Then, the catalyst was filtered off, washed with warm methanol, and the combined filtrates were evaporated to give 0.14 g (50%) of C-(3-amino-phenyl)-N-(3-methoxy-propyl)-methanesulfonamide

후처리

  1. filtrationThen, the catalyst was filtered off
  2. washwashed with warm methanol
  3. customthe combined filtrates were evaporated

출처 및 근거

ORD 기록
ord-db00cdd34a224693b4b924da31888435
출처 데이터셋
uspto-grants-2013_03
특허 번호
US08389521B2

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