Iodine → 4-Bromo-2-iodo-6-nitroaniline

HRID 1941917

반응식

HRID 1941917 반응식
[Br:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[C:4]([N+:9]([O-:11])=[O:10])[CH:3]=1.[I:12]I>C(O)C.S([O-])([O-])(=O)=O.[Ag+].[Ag+]>[Br:1][C:2]1[CH:3]=[C:4]([N+:9]([O-:11])=[O:10])[C:5]([NH2:6])=[C:7]([I:12])[CH:8]=1

참가 물질

5

반응물 2

HCID 807IodineHCID 701324-Bromo-2-nitroaniline

생성물 1

HCID 106887094-Bromo-2-iodo-6-nitroaniline수율 88%

시약·촉매·용매 2

HCID 159865Silver sulfate촉매HCID 702Ethanol용매

실험 절차

4-Bromo-2-nitroaniline (14.3 g, 0.0659 mol) was added in one portion to iodine (17.6 g, 0.0692 mol) dissolved in ethanol (300 ml), followed by silver (I) sulphate (20.4 g 0.0659 mol). After stirring at ambient temperature for 18 hours the reaction was filtered and the solid obtained was washed with dichloromethane until all the orange product had dissolved. The combined filtrates were evaporated in vacuo and the resulting solid was washed with diethyl ether/40-60 Petroleum ether (1:1) and filtered to give 4-bromo-2-iodo-6-nitroaniline as an orange solid (19.8 g, 88%), which was used without further purification.

후처리

  1. filtrationwas filtered
  2. customthe solid obtained
  3. washwas washed with dichloromethane until all the orange product
  4. dissolutionhad dissolved
  5. customThe combined filtrates were evaporated in vacuo
  6. washthe resulting solid was washed with diethyl ether/40-60 Petroleum ether (1:1)
  7. filtrationfiltered

출처 및 근거

ORD 기록
ord-54557a36fd9448bfb384bda60fb8b6b2
출처 데이터셋
uspto-grants-2013_03
특허 번호
US08389516B2

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