Sodium borohydride → 1-(5,6-Dichloro-pyridin-3-yl)-ethanol
반응식
[BH4-].[Na+].[Cl:3][C:4]1[CH:5]=[C:6]([C:11](=[O:13])[CH3:12])[CH:7]=[N:8][C:9]=1[Cl:10]>CO>[Cl:3][C:4]1[CH:5]=[C:6]([CH:11]([OH:13])[CH3:12])[CH:7]=[N:8][C:9]=1[Cl:10]참가 물질
4
반응 조건
- 온도
- 0 °C
실험 절차
To a well stirred suspension of sodium borohydride (66.21 g, 1.75 mole) in methanol (3.5 L) cooled to 0° C. with a Dry Ice/acetone bath was added 1-(5,6-dichloro-pyridin-3-yl)-ethanone 14 (665 g, 3.5 mole) at a rate such that the temperature remained at 0° C. After solid addition was complete, the reaction mixture was stirred an additional 1 h, after which time LC/MS analysis of an aliquot showed that the reaction was complete.
후처리
- customremained at 0° C
- additionAfter solid addition
- stirringthe reaction mixture was stirred an additional 1 h
출처 및 근거
- ORD 기록
- ord-cfc05fd34df94ca4bcf4a2f634328554
- 출처 데이터셋
- uspto-grants-2013_03
- 특허 번호
- US08389549B2
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