Water → 4-{[Propyl-(4,5,6,7-tetrahydro-benzothiazol-6-yl)-amino]-methyl}-benzoic acid

HRID 1942397노트

반응식

HRID 1942397 반응식
C[O:2][C:3](=[O:24])[C:4]1[CH:9]=[CH:8][C:7]([CH2:10][N:11]([CH2:21][CH2:22][CH3:23])[CH:12]2[CH2:20][CH2:19][C:15]3[N:16]=[CH:17][S:18][C:14]=3[CH2:13]2)=[CH:6][CH:5]=1.[OH-].[Na+].O>C(O)(=O)C>[CH2:21]([N:11]([CH2:10][C:7]1[CH:6]=[CH:5][C:4]([C:3]([OH:24])=[O:2])=[CH:9][CH:8]=1)[CH:12]1[CH2:20][CH2:19][C:15]2[N:16]=[CH:17][S:18][C:14]=2[CH2:13]1)[CH2:22][CH3:23]

참가 물질

5

반응물 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 866513134-{[Propyl-(4,5,6,7-tetrahydrobenzothiazol-6-yl)amino]methyl}benzoic acid methylester

생성물 1

HCID 669374084-{[Propyl-(4,5,6,7-tetrahydro-benzothiazol-6-yl)-amino]-methyl}-benzoic acid

시약·촉매·용매 1

HCID 176Acetic Acid용매

반응 조건

온도
80 °C

실험 절차

A mixture of 1.93 g (5.6 mmol) 42A, 840 mg (21 mmol) sodium hydroxide and 25 mL water is stirred for 4 hours at 80° C. The mixture is allowed to cool to room temperature and then neutralized with acetic acid and extracted three times with dichloromethane. The combined organic fractions are dried with sodium sulfate, and the solvent is evaporated in vacuum.

후처리

  1. temperatureto cool to room temperature
  2. extractionextracted three times with dichloromethane
  3. dry with materialThe combined organic fractions are dried with sodium sulfate
  4. customthe solvent is evaporated in vacuum

출처 및 근거

ORD 기록
ord-7c877cc7518746599f23fd706423cb06
출처 데이터셋
uspto-grants-2013_03
특허 번호
US08389555B2

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