Acetic Acid → Phenoxyacetaldehyde

HRID 1942441

반응식

HRID 1942441 반응식
C([O:3][CH:4](OCC)[CH2:5][O:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)C.C(O)(=O)C.Cl>C(O)C>[O:6]([CH2:5][CH:4]=[O:3])[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1

참가 물질

5

반응물 3

HCID 176Acetic AcidHCID 313Hydrochloric AcidHCID 96328(2,2-Diethoxyethoxy)benzene

생성물 1

HCID 75033Phenoxyacetaldehyde

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

0.84 g (4 mmol) of 69A, 5 mL of acetic acid, 2.5 mL of 1N aqueous hydrochloric acid and 20 mL of ethanol were mixed and heated under reflux under an argon atmosphere for 3 hours. Ethanol was evaporated. Then the resulting residue was dispersed in dichloromethane and extracted with saturated sodium bicarbonate solution. The organic phase was dried with sodium sulfate and the solvent evaporated in vacuum. The crude product was obtained in almost quantitative yield.

후처리

  1. temperatureheated
  2. temperatureunder reflux under an argon atmosphere for 3 hours
  3. customEthanol was evaporated
  4. additionThen the resulting residue was dispersed in dichloromethane
  5. extractionextracted with saturated sodium bicarbonate solution
  6. dry with materialThe organic phase was dried with sodium sulfate
  7. customthe solvent evaporated in vacuum

출처 및 근거

ORD 기록
ord-2ec187ccb9594cdb8a00a7050c53f9f6
출처 데이터셋
uspto-grants-2013_03
특허 번호
US08389555B2

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