Sodium Hydroxide → 6-bromo-3,3-dimethyl-2,3-dihydro-1H-indol-2-one

HRID 1942535노트

반응식

HRID 1942535 반응식
C([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([Br:13])[CH:11]=2)[C:6]([CH3:15])([CH3:14])[C:5]1=[O:16])(=O)C.[OH-].[Na+]>CCO>[Br:13][C:10]1[CH:11]=[C:12]2[C:7]([C:6]([CH3:15])([CH3:14])[C:5](=[O:16])[NH:4]2)=[CH:8][CH:9]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 108267191-Acetyl-6-bromo-3,3-dimethylindolin-2-one

생성물 1

HCID 106576496-bromo-3,3-dimethyl-2,3-dihydro-1H-indol-2-one

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To 1-acetyl-6-bromo-3,3-dimethyl-1,3-dihydro-2H-indol-2-one (5.2 g) were added 1N aqueous NaOH solution (11 ml) and EtOH (44 ml), and the mixture was stirred at room temperature for one hour. After the reaction was complete, the solvent was concentrated, and thereto was added dropwise a 2N aqueous hydrochloric acid solution. The precipitated crystals were extracted with ethyl acetate, and this ethyl acetate solution was washed with water and an aqueous sodium chloride solution, dried over magnesium sulfate, filtered, and concentrated. The obtained residue (4.1 g) was used in the subsequent reaction without further treatment.

후처리

  1. concentrationthe solvent was concentrated
  2. additionwas added dropwise a 2N aqueous hydrochloric acid solution
  3. extractionThe precipitated crystals were extracted with ethyl acetate
  4. washthis ethyl acetate solution was washed with water
  5. dry with materialan aqueous sodium chloride solution, dried over magnesium sulfate
  6. filtrationfiltered
  7. concentrationconcentrated
  8. customThe obtained residue (4.1 g) was used in the subsequent reaction without further treatment

출처 및 근거

ORD 기록
ord-25f6ec45238042daac82a1deb755f243
출처 데이터셋
uspto-grants-2013_03
특허 번호
US08389511B2

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