Isopropanol → HCID 58404446, 화합물

HRID 1942583노트

반응식

HRID 1942583 반응식
F[C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][C:3]=1[C:10]([F:13])([F:12])[F:11].[CH3:14][CH:15]([OH:17])[CH3:16].[H-].[Na+]>O1CCCC1>[CH3:14][CH:15]([O:17][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][C:3]=1[C:10]([F:13])([F:12])[F:11])[CH3:16]

참가 물질

5

반응물 3

HCID 3776IsopropanolHCID 24758Sodium hydrideHCID 1442554-Fluoro-3-(trifluoromethyl)benzonitrile

생성물 1

HCID 58404446HCID 58404446, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

반응 조건

온도
-10 °C

실험 절차

To a solution of 4-fluoro-3-(trifluoromethyl)benzonitrile (10 g), i-PrOH (8.15 mL) in tetrahydrofuran (THF) (90 mL) stirred under nitrogen at −10° C. was added solid NaH (3.46 g) portionwise during 30 min. The reaction mixture was stirred at −10° C. for 6 h. The reaction mixture was quenched with water, partitioned between ether (100 mL) and water (50 mL). The organic phase was dried over magnesium sulphate and evaporated in vacuo to give the crude product 4-[(1-methylethyl)oxy]-3-(trifluoromethyl)benzonitrile (D10) (15 g).

후처리

  1. customThe reaction mixture was quenched with water
  2. custompartitioned between ether (100 mL) and water (50 mL)
  3. dry with materialThe organic phase was dried over magnesium sulphate
  4. customevaporated in vacuo

출처 및 근거

ORD 기록
ord-012129b40fcc43a78051dac56f5f4c69
출처 데이터셋
uspto-grants-2013_03
특허 번호
US08389508B2

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