Potassium Carbonate → 6-[(E)-2-Phenylethenyl][1,2,5]thiadiazolo[3,4-b]pyridine

HRID 1943231노트

반응식

HRID 1943231 반응식
Br[C:2]1[CH:7]=[N:6][C:5]2=[N:8][S:9][N:10]=[C:4]2[CH:3]=1.[C:11]1(/[CH:17]=[CH:18]/B(O)O)[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1.O1CCOCC1.C(=O)([O-])[O-].[K+].[K+]>O>[C:11]1(/[CH:17]=[CH:18]/[C:2]2[CH:7]=[N:6][C:5]3=[N:8][S:9][N:10]=[C:4]3[CH:3]=2)[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

참가 물질

6

반응물 4

HCID 11430Potassium CarbonateHCID 312751,4-DioxaneHCID 3616936-Bromo[1,2,5]thiadiazolo[3,4-b]pyridineHCID 5702628Styrylboronic acid

생성물 1

HCID 685963166-[(E)-2-Phenylethenyl][1,2,5]thiadiazolo[3,4-b]pyridine

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To 6-bromo[1,2,5]thiadiazolo[3,4-b]pyridine (for a preparation see Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry (1979), 17B(1), 13-16) (1.9 g, 8.79 mmol), [(E)-2-phenylethenyl]boronic acid (1.561 g, 10.55 mmol) and tetrakistriphenylphosphine palladium(0) (0.508 g, 0.440 mmol) was added 1,4-dioxane (38 ml) and then potassium carbonate (1.276 g, 9.23 mmol) in water (19 ml). The reaction was then stirred at reflux for 1.5 hours. The cooled reaction was partitioned between chloroform and water. The phases were separated with a hydrophobic frit and the organic extracts concentrated to give a black solid/gum (˜2.4 g). This crude material was purified by chromatography on silica eluting with 20-50% EtOAc in cyclohexane to give the product as a yellow/brown solid (0.88 g).

후처리

  1. temperatureat reflux for 1.5 hours
  2. customThe cooled reaction
  3. customwas partitioned between chloroform and water
  4. customThe phases were separated with a hydrophobic frit
  5. concentrationthe organic extracts concentrated

출처 및 근거

ORD 기록
ord-6ac3c1d9c72b4e2ab350ab1da417ab32
출처 데이터셋
uspto-grants-2013_03
특허 번호
US08389524B2

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