Hydrazine hydrate (1:1) → HCID 55285667, 화합물

HRID 1943931노트

반응식

HRID 1943931 반응식
[CH:1]([NH:4]/[C:5](/SC)=[CH:6]/[C:7]#[N:8])([CH3:3])[CH3:2].O.[NH2:12][NH2:13]>CCO>[CH:1]([NH:4][C:5]1[CH:6]=[C:7]([NH2:8])[NH:13][N:12]=1)([CH3:3])[CH3:2]

참가 물질

4

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 86652503(2Z)-3-[(1-Methylethyl)amino]-3-(methylthio)-2-propenenitrile

생성물 1

HCID 55285667HCID 55285667, 화합물수율 62.4%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of (Z)-3-(isopropylamino)-3-(methylthio)acrylonitrile (0.413 g, 2.64 mmol) and hydrazine monohydrate (0.38 mL, 7.93 mmol) in EtOH (6 mL) was heated to reflux for 16 hours. After cooling to room temperature, the reaction mixture was concentrated. The residue was purified by column chromatography, eluting with ethyl acetate, DCM/MeOH (9:1) to give N3-isopropyl-1H-pyrazole-3,5-diamine (0.231 g, 62% over 2 steps) as an oil.

후처리

  1. temperaturewas heated
  2. temperatureto reflux for 16 hours
  3. concentrationthe reaction mixture was concentrated
  4. customThe residue was purified by column chromatography
  5. washeluting with ethyl acetate, DCM/MeOH (9:1)

출처 및 근거

ORD 기록
ord-1aa0d19f5a26406592838b4bfdc8bdfc
출처 데이터셋
uspto-grants-2013_03
특허 번호
US08394795B2

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