Dimethyl Sulfoxide → 3-(Pyridine-3-sulfonyl)thiophene-2-carbaldehyde

HRID 1944434노트

반응식

HRID 1944434 반응식
Cl[C:2]1[CH:6]=[CH:5][S:4][C:3]=1[CH:7]=[O:8].[Na+].[N:10]1[CH:15]=[CH:14][CH:13]=[C:12]([S:16]([O-:18])=[O:17])[CH:11]=1.CS(C)=O>O>[N:10]1[CH:15]=[CH:14][CH:13]=[C:12]([S:16]([C:2]2[CH:6]=[CH:5][S:4][C:3]=2[CH:7]=[O:8])(=[O:18])=[O:17])[CH:11]=1

참가 물질

5

반응물 3

HCID 679Dimethyl SulfoxideHCID 27358253-Chlorothiophene-2-carbaldehydeHCID 23697071Sodium pyridine-3-sulfinate

생성물 1

HCID 866521933-(Pyridine-3-sulfonyl)thiophene-2-carbaldehyde수율 28.6%

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
80 °C

실험 절차

A mixture of 3-chlorothiophene-2-carbaldehyde (0.16 g), pyridine-3-sulfinic acid sodium salt (0.30 g) and dimethyl sulfoxide (2.0 mL) was heated at 80° C. for 3 hours and then at 90° C. for 3 hours. The mixture was diluted with water, extracted with ethyl acetate and the combined organic extract was dried over magnesium sulfate. The solvent was removed under reduced pressure to afford the title compound as a grey solid (0.079 g).

후처리

  1. extractionextracted with ethyl acetate
  2. extractionthe combined organic extract
  3. dry with materialwas dried over magnesium sulfate
  4. customThe solvent was removed under reduced pressure

출처 및 근거

ORD 기록
ord-0017927d9ad14a2eb52085da64a7ee85
출처 데이터셋
uspto-grants-2013_03
특허 번호
US08394836B2

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