Benzenesulfinic acid, sodium salt → 4-Benzenesulfonylthiazole-5-carbaldehyde

HRID 1944481노트

반응식

HRID 1944481 반응식
Cl[C:2]1[N:3]=[CH:4][S:5][C:6]=1[CH:7]=[O:8].[Na+].[C:10]1([S:16]([O-:18])=[O:17])[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1>CS(C)=O>[C:10]1([S:16]([C:2]2[N:3]=[CH:4][S:5][C:6]=2[CH:7]=[O:8])(=[O:18])=[O:17])[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1

참가 물질

4

반응물 2

HCID 2723840Benzenesulfinic acid, sodium saltHCID 145013174-Chloro-1,3-thiazole-5-carbaldehyde

생성물 1

HCID 866522084-Benzenesulfonylthiazole-5-carbaldehyde수율 89.3%

시약·촉매·용매 1

HCID 679Dimethyl Sulfoxide용매

반응 조건

온도
100 °C

실험 절차

A mixture of 4-chlorothiazole-5-carbaldehyde (0.15 g), benzenesulfinic acid sodium salt (0.25 g) and dimethyl sulfoxide (7.0 mL) was stirred at 100° C. for 30 minutes. The mixture was cooled to room temperature, poured onto ice/water (50 mL) and extracted with ethyl acetate. The combined organic extract was washed with saturated aqueous sodium chloride solution and dried over magnesium sulfate. The solvent was removed under reduced pressure to afford the title compound as a tan oil (0.23 g).

후처리

  1. temperatureThe mixture was cooled to room temperature
  2. additionpoured onto ice/water (50 mL)
  3. extractionextracted with ethyl acetate
  4. extractionThe combined organic extract
  5. washwas washed with saturated aqueous sodium chloride solution
  6. dry with materialdried over magnesium sulfate
  7. customThe solvent was removed under reduced pressure

출처 및 근거

ORD 기록
ord-2a6ec8581a2b4a66bf1d7500efc21129
출처 데이터셋
uspto-grants-2013_03
특허 번호
US08394836B2

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