Triphenylphosphine → 5-Chloro-2-methoxybenzene-1-thiol

HRID 1945184노트

반응식

HRID 1945184 반응식
C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.[Cl:20][C:21]1[CH:22]=[CH:23][C:24]([O:31][CH3:32])=[C:25]([S:27](Cl)(=O)=O)[CH:26]=1>C1COCC1.O>[Cl:20][C:21]1[CH:22]=[CH:23][C:24]([O:31][CH3:32])=[C:25]([SH:27])[CH:26]=1

참가 물질

5

반응물 2

HCID 11776TriphenylphosphineHCID 27342725-Chloro-2-methoxybenzene-1-sulfonyl chloride

생성물 1

HCID 127727855-Chloro-2-methoxybenzene-1-thiol

시약·촉매·용매 2

HCID 962Water용매2회HCID 8028Tetrahydrofuran용매

실험 절차

Triphenylphosphine (11.4 g) was added portionwise to a stirred solution of 5-chloro-2-methoxybenzenesulphonyl chloride (3.0 g) in THF (30 ml). Water (4 ml) was added and the mixture stirred at RT for 2 h, afterwhich the reaction was diluted with water (25 ml) then 2M sodium hydroxide solution and washed with ether. The aqueous layer was acidified with 2M hydrochloric acid and extracted with ethylacetate. The organic layer was dried and evaporated under reduced pressure, yield 3.1 g.

후처리

  1. wash2M sodium hydroxide solution and washed with ether
  2. extractionextracted with ethylacetate
  3. customThe organic layer was dried
  4. customevaporated under reduced pressure, yield 3.1 g

출처 및 근거

ORD 기록
ord-b366c001068c4a8fb6223053a0a429ff
출처 데이터셋
uspto-grants-2013_03
특허 번호
US08394986B2

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