Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-cyclopropyl-1H-1,3-benzodiazole → ethyl 2-(4-((2-(2-cyclopropyl-1H-benzo[d]imidazol-1-yl)-9-methyl-6-morpholino-9H-purin-8-yl)methyl)piperazin-1-yl)-2-methylpropanoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-cyclopropyl-1H-1,3-benzodiazole | HCID 1084419 | — |
| 반응물 | ethyl 2-(4-((2-chloro-9-methyl-6-morpholino-9H-purin-8-yl)methyl)piperazin-1-yl)-2-methylpropanoate | HCID 86648267 | — |
| 생성물 | ethyl 2-(4-((2-(2-cyclopropyl-1H-benzo[d]imidazol-1-yl)-9-methyl-6-morpholino-9H-purin-8-yl)methyl)piperazin-1-yl)-2-methylpropanoate | HCID 59606061 | — |
반응 단계
Following General Procedure I for Buchwald coupling, 2-cyclopropylbenzimidazole and ethyl 2-(4-((2-chloro-9-methyl-6-morpholino-9H-purin-8-yl)methyl)piperazin-1-yl)-2-methylpropanoate were reacted to give 500. LCMS m/z: 588.4 (MH+)
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08394796B2 |
| 출처 데이터셋 | uspto-grants-2013_03 |
| ORD ID | ord-627e16e5914144bfbfaa5111362f764c |
| 출처 메모 | uspto-grants-2013_03 |