Acetic Acid → 4(1H)-Pyrimidinone, 2-(butylthio)-

HRID 1946981

반응식

HRID 1946981 반응식
[S:1]=[C:2]1[NH:7][C:6](=[O:8])[CH:5]=[CH:4][NH:3]1.[OH-].[Na+].[CH2:11](I)[CH2:12][CH2:13][CH3:14].C(O)(=O)C>O>[CH2:11]([S:1][C:2]1[NH:7][C:6](=[O:8])[CH:5]=[CH:4][N:3]=1)[CH2:12][CH2:13][CH3:14]

참가 물질

6

반응물 4

HCID 176Acetic AcidHCID 10962Butyl iodide3회HCID 14798Sodium HydroxideHCID 1269845Thiouracil

생성물 1

HCID 5342184(1H)-Pyrimidinone, 2-(butylthio)-

시약·촉매·용매 1

HCID 962Water용매

실험 절차

2-Thioxo-2,3-dihydro-1H-pyrimidin-4-one (12.8 g) was added to a solution of NaOH (8.0 g) in water (70 mL). After complete dissolution of the solids butyl iodide (12.4 mL) was added to the solution and the resulting mixture was stirred at RT overnight. A second aliquot of butyl iodide (1.2 mL) was then added and the reaction mixture was stirred for 24 h. A third aliquot of butyl iodide (1.2 mL) was added and the resulting mixture was stirred for 6 days. Glacial acetic acid (5.5 mL) was added and the reaction mixture was stirred for 30 min, it was then stored at 4° C. overnight. The precipitate formed was collected by filtration and dried under reduced pressure to give 12.3 g of 2-butylsulfanyl-3H-pyrimidin-4-one.

후처리

  1. additionwas added to the solution
  2. stirringthe reaction mixture was stirred for 24 h
  3. stirringthe resulting mixture was stirred for 6 days
  4. stirringthe reaction mixture was stirred for 30 min
  5. waitit was then stored at 4° C. overnight
  6. customThe precipitate formed
  7. filtrationwas collected by filtration
  8. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-ebb20cb6aad14451816afaa1dea67da8
출처 데이터셋
uspto-grants-2013_03
특허 번호
US08399462B2

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