Acetic Anhydride → N-{1-[1-(4-Chloro-benzoyl)-4-hydroxy-pyrrolidin-3-yl]-piperidin-4-yl}-N-(4-chloro-phenyl)-acetamide

HRID 1947090노트

반응식

HRID 1947090 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([N:10]2[CH2:14][CH:13]([OH:15])[CH:12]([N:16]3[CH2:21][CH2:20][CH:19]([NH:22][C:23]4[CH:28]=[CH:27][C:26]([Cl:29])=[CH:25][CH:24]=4)[CH2:18][CH2:17]3)[CH2:11]2)=[O:9])=[CH:4][CH:3]=1.[CH3:30][C:31](OC(C)=O)=[O:32]>N1C=CC=CC=1>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]([N:10]2[CH2:14][CH:13]([OH:15])[CH:12]([N:16]3[CH2:17][CH2:18][CH:19]([N:22]([C:23]4[CH:24]=[CH:25][C:26]([Cl:29])=[CH:27][CH:28]=4)[C:31](=[O:32])[CH3:30])[CH2:20][CH2:21]3)[CH2:11]2)=[O:9])=[CH:6][CH:7]=1

참가 물질

4

반응물 2

HCID 7918Acetic AnhydrideHCID 68512735HCID 68512735, 화합물

생성물 1

HCID 68511424N-{1-[1-(4-Chloro-benzoyl)-4-hydroxy-pyrrolidin-3-yl]-piperidin-4-yl}-N-(4-chloro-phenyl)-acetamide

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

The starting materials (4-Chloro-phenyl)-{3-[4-(4-chloro-phenylamino)-piperidin-1-yl]-4-hydroxy-pyrrolidin-1-yl}-methanone (48 mg, 0.11 mmol) and Ac2O (16 uL, 0.17 mmol) were added in pyridine (0.5 mL) and stirred at room temperature overnight. The reaction mixture was concentrated down to dryness. The resulting crude residue was purified by column chromatography on silica (Methanol\CH2Cl2: 0%-6%).

후처리

  1. concentrationThe reaction mixture was concentrated down to dryness
  2. customThe resulting crude residue was purified by column chromatography on silica (Methanol\CH2Cl2: 0%-6%)

출처 및 근거

ORD 기록
ord-1e0ea49ce912489cb1e77d99328fd32a
출처 데이터셋
uspto-grants-2013_03
특허 번호
US08399455B2

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