Methanol → 6-Isopropoxypyrimidine-2,4-diamine

HRID 1947244노트

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HRID 1947244 반응식
[H-].[Na+].[NH2:3][C:4]1[N:9]=[C:8]([OH:10])[CH:7]=[C:6]([NH2:11])[N:5]=1.[CH:12](Br)([CH3:14])[CH3:13].CO>CN(C=O)C>[CH:12]([O:10][C:8]1[N:9]=[C:4]([NH2:3])[N:5]=[C:6]([NH2:11])[CH:7]=1)([CH3:14])[CH3:13]

참가 물질

6

반응물 4

HCID 887MethanolHCID 63582-BromopropaneHCID 24758Sodium hydrideHCID 178507952HCID 178507952, 화합물

생성물 1

HCID 591869186-Isopropoxypyrimidine-2,4-diamine

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

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온도
40 °C

실험 절차

634 mg of sodium hydride (60% in mineral oil, 17.12 mmol) are added in portions under an argon atmosphere to a vigorously stirred solution of 1.8 g (14.27 mmol) of 2,6-diaminopyrimidin-4-ol in 20 ml of DMF. After 30 min, 1.6 ml (17.12 mmol) of isopropyl bromide are added dropwise, and the solution is stirred at 40° C. for 12 h. Methanol (1 mol) is then added to the reaction mixture, which is directly purified by preparative HPLC. Combining the product fractions and removing the solvent result in 250 mg (12% of theory) of the title compound as a white solid.

후처리

  1. customis directly purified by preparative HPLC
  2. customremoving the solvent

출처 및 근거

ORD 기록
ord-db5fb98a943a402caf8c7c4af9d3b453
출처 데이터셋
uspto-grants-2013_03
특허 번호
US08399471B2

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