HCID 57907619, 화합물 → [(5S)-6,7-Dihydro-5H-pyrrolo[1,2-b][1,2,4]triazol-5-yl]methanol
반응식
C([O:20][CH2:21][C@H:22]1[N:26]2[N:27]=[CH:28][N:29]=[C:25]2[CH2:24][CH2:23]1)(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1>Cl.O1CCOCC1>[N:29]1[CH:28]=[N:27][N:26]2[C@H:22]([CH2:21][OH:20])[CH2:23][CH2:24][C:25]=12참가 물질
4
실험 절차
The product form step B above, 0.27 g (0.71 mmol) of (5S)-5-[(trityloxy)methyl]-6,7-dihydro-5H-pyrrolo[1,2-b][1,2,4]triazole, was dissolved in 35 mL of a 4.0 M solution of hydrogen chloride in anhydrous 1,4-dioxane. The reaction mixture was stirred for 10 min, quenched with 20 mL of methanol, then evaporated to dryness in vacuo. The residue was purified by reverse phase HPLC (TMC Pro-Pac C18; 0-90% 0.1% trifluoroacetic acid in acetonitrile/0.1% trifluoroacetic acid in water gradient) to yield the title compound (0.050 g, 50%). LC-MS: m/z (ES) 140 (MH)+.
후처리
- customquenched with 20 mL of methanol
- customevaporated to dryness in vacuo
- customThe residue was purified by reverse phase HPLC (TMC Pro-Pac C18; 0-90% 0.1% trifluoroacetic acid in acetonitrile/0.1% trifluoroacetic acid in water gradient)
출처 및 근거
- ORD 기록
- ord-ac717dd5a79a4c61ab30321b44959324
- 출처 데이터셋
- uspto-grants-2013_03
- 특허 번호
- US08399480B2
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