3-Fluorobenzyl bromide → 5-Bromo-1-(3-fluorobenzyl)pyridin-2(1H)-one

HRID 1948195

반응식

HRID 1948195 반응식
[Br:1][C:2]1[CH:3]=[CH:4][C:5](=[O:8])[NH:6][CH:7]=1.[F:9][C:10]1[CH:11]=[C:12]([CH:15]=[CH:16][CH:17]=1)[CH2:13]Br>>[F:9][C:10]1[CH:11]=[C:12]([CH:15]=[CH:16][CH:17]=1)[CH2:13][N:6]1[CH:7]=[C:2]([Br:1])[CH:3]=[CH:4][C:5]1=[O:8]

참가 물질

3

반응물 2

HCID 680073-Fluorobenzyl bromideHCID 5995285-Bromo-2-hydroxypyridine

생성물 1

HCID 606276535-Bromo-1-(3-fluorobenzyl)pyridin-2(1H)-one수율 62%

실험 절차

According to Scheme 1 Step 2: 1-(3-Fluorobenzyl)-5-bromopyridin-2(1H)-one was prepared from 5-bromopyridin-2(1H)-one (Example 1 Step 1) and 3-fluorobenzyl bromide according to the procedure described for Example 2 Step 1. The crude product washed with pentane/Et2O 50/50 to afford 1-(3-fluorobenzyl)-5-bromopyridin-2(1H)-one (10.7 mmol, 3.00 g, 62%) as a white solid.

후처리

  1. washThe crude product washed with pentane/Et2O 50/50

출처 및 근거

ORD 기록
ord-0392181931214d6895b9cc6ab62bf4a2
출처 데이터셋
uspto-grants-2013_03
특허 번호
US08399493B2

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