Methyl iodide → 1-(4-chlorobenzyl)-4-(2-methoxyethyl)-5-(4-methoxyphenyl)pyridin-2(1H)-one

HRID 1948270노트

반응식

HRID 1948270 반응식
[Cl:1][C:2]1[CH:26]=[CH:25][C:5]([CH2:6][N:7]2[CH:12]=[C:11]([C:13]3[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[CH:15][CH:14]=3)[C:10]([CH2:21][CH2:22][OH:23])=[CH:9][C:8]2=[O:24])=[CH:4][CH:3]=1.I[CH3:28]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][N:7]2[CH:12]=[C:11]([C:13]3[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[CH:15][CH:14]=3)[CH:10]([CH2:21][CH2:22][O:23][CH3:28])[CH2:9][C:8]2=[O:24])=[CH:25][CH:26]=1.[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][N:7]2[CH:12]=[C:11]([C:13]3[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[CH:15][CH:14]=3)[C:10]([CH2:21][CH2:22][O:23][CH3:28])=[CH:9][C:8]2=[O:24])=[CH:25][CH:26]=1

참가 물질

4

반응물 2

HCID 6328Methyl iodideHCID 693503681-(4-chlorobenzyl)-4-(2-hydroxyethyl)-5-(4-methoxyphenyl)pyridin-2(1H)-one

생성물 2

HCID 589669471-(4-chlorobenzyl)-4-(2-methoxyethyl)-5-(4-methoxyphenyl)pyridin-2(1H)-one수율 171.4%HCID 694427411-(4-Chlorobenzyl)-4-(2-methoxyethyl)-5-(4-methoxyphenyl)pyridin-2(4H)-one

실험 절차

According to Scheme 30 Step 4: The title compound was prepared from 1-(4-chlorobenzyl)-4-(2-hydroxyethyl)-5-(4-methoxyphenyl)pyridin-2(1H)-one (1 eq, 0.14 mmol, 50 mg) and iodomethane (3 eq, 0.41 mmol, 58 mg) according to the procedure described for Example 34 Step 3. The product was further purified by flash chromatography over silica gel (AIT Flashsmart prepacked column 5 g SiO2) using Et2O/pentane 90/10 to afford 1-(4-chlorobenzyl)-4-(2-methoxyethyl)-5-(4-methoxyphenyl)pyridin-2(1H)-one (0.12 mmol, 47 mg, 91%) as a colorless oil.

후처리

  1. customThe product was further purified by flash chromatography over silica gel (AIT Flashsmart prepacked column 5 g SiO2)

출처 및 근거

ORD 기록
ord-bd47c347013a405faf28101f1efaebf5
출처 데이터셋
uspto-grants-2013_03
특허 번호
US08399493B2

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