Methyl iodide → Benzyl [(1R)-2-methoxy-1-methylethyl]carbamate
반응식
[OH:1][CH2:2][C@H:3]([NH:5][C:6](=[O:15])[O:7][CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[CH3:4].[CH3:16]I>C(#N)C.[Ag]=O>[CH3:16][O:1][CH2:2][C@H:3]([NH:5][C:6](=[O:15])[O:7][CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[CH3:4]참가 물질
5
실험 절차
To a solution of benzyl [(1R)-2-hydroxy-1-methylethyl]carbamate (0.5 g, 2.38 mmol) in acetonitrile (20 mL), silver oxide (3.8 g, 13.09 mmol) is added followed by the addition of methyl iodide (1.94 mL, 23.8 mmol). The resultant mixture was stirred overnight at room temperature. The insoluble salt was filtered off and the filtrate was concentrated. The residue was flashed using silica and Ethyl acetate/hexanes system as eluent to give the desired product as clear oil (0.38 g).
후처리
- filtrationThe insoluble salt was filtered off
- concentrationthe filtrate was concentrated
출처 및 근거
- ORD 기록
- ord-623a13dc66014028b2ce2f1c8414dec1
- 출처 데이터셋
- uspto-grants-2013_03
- 특허 번호
- US08399489B2
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