HCID 68841469, 화합물 → HCID 68694413, 화합물
반응식
Cl.[CH2:2]([C:4]1([N:14]([CH3:16])[CH3:15])[CH2:13][CH2:12][C:7]2(OCC[O:8]2)[CH2:6][CH2:5]1)[CH3:3]>Cl>[CH3:15][N:14]([CH3:16])[C:4]1([CH2:2][CH3:3])[CH2:13][CH2:12][C:7](=[O:8])[CH2:6][CH2:5]1참가 물질
3
실험 절차
(8-ethyl-1,4-dioxa-spiro[4.5]dec-8-yl)-dimethylamine hydrochloride (6.67 g, 0.026 mmole) was dissolved in 6N HCl (40 ml) and stirred overnight at room temperature. The reaction mixture was extracted twice with diethyl ether (100 ml). The reaction mixture was then made alkaline with 5N NaOH while cooling with ice and extracted a further three times with Et2O (100 ml). The combined organic phases were dried over Na2SO4, filtered, and the solvent was removed in vacuo.
후처리
- extractionThe reaction mixture was extracted twice with diethyl ether (100 ml)
- temperaturewhile cooling with ice
- extractionextracted a further three times with Et2O (100 ml)
- dry with materialThe combined organic phases were dried over Na2SO4
- filtrationfiltered
- customthe solvent was removed in vacuo
출처 및 근거
- ORD 기록
- ord-445d560e766b4c92bbfad8705a355321
- 출처 데이터셋
- uspto-grants-2013_03
- 특허 번호
- US08399503B2
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