L-Lysine → 7-Amino-2-oxoheptanoic acid

반응식

[NH2:1][C@H:2](C(O)=O)CCCCN.N[CH2:12][CH2:13][CH2:14][CH2:15][C:16](=[O:20])[C:17]([OH:19])=[O:18]>>[NH2:1][CH2:2][CH2:12][CH2:13][CH2:14][CH2:15][C:16](=[O:20])[C:17]([OH:19])=[O:18]

참가 물질

반응물 2

HCID 5962L-Lysine

HCID 4399546-Amino-2-oxohexanoic acid2회

생성물 1

HCID 574852297-Amino-2-oxoheptanoic acid

실험 절차

In an alternative embodiment, lysine is first converted to 6-amino-2-oxohexanoic acid by an aminotransferase enzyme (EC 2.6.1.x) or a dehydrogenase (EC 1.4.1.x or EC 1.4.3.x). Preferred enzymes are listed in Table 7 and may be engineered to catalyze the desired substrate to product reaction. In a subsequent step, 6-amino-2-oxohexanoic acid is subjected to a carbon elongation enzymatic step to produce 7-amino-2-oxoheptanoic acid.

후처리

customto product reaction

출처 및 근거

ORD 기록: ord-b8f58644838640a4b61f784a02a4b55e
출처 데이터셋: uspto-grants-2013_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08404465B2

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