Hydroxylamine → 2-ethoxy-N'-hydroxybenzenecarboximidamide

HRID 1950798

반응식

HRID 1950798 반응식
[NH2:1][OH:2].[CH2:3]([O:5][C:6]1[CH:13]=[CH:12][CH:11]=[CH:10][C:7]=1[C:8]#[N:9])[CH3:4]>CCO>[CH2:3]([O:5][C:6]1[CH:13]=[CH:12][CH:11]=[CH:10][C:7]=1[C:8](=[N:1][OH:2])[NH2:9])[CH3:4]

참가 물질

4

반응물 2

HCID 787HydroxylamineHCID 5769222-Ethoxybenzonitrile

생성물 1

HCID 40567362-ethoxy-N'-hydroxybenzenecarboximidamide수율 97.2%

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
50 °C

실험 절차

Hydroxylamine (Fluka 55458; 50% in water; 4.08 mL; 67.95 mmol; 5 eq.) was added to a solution of 2-ethoxybenzonitrile (Fluorochem 18661; 2 g; 13.59 mmol; 1 eq.) in EtOH (30 mL) and the reaction mixture was stirred at 50° C. for 12 hours. Evaporation in vacuo gave a white solid, which was further dried under high vacuum to afford the title compound (2.38 g, 97%) as a white solid.

후처리

  1. customEvaporation in vacuo
  2. customgave a white solid, which
  3. customwas further dried under high vacuum

출처 및 근거

ORD 기록
ord-221697abe7f944b09464f196de649a4e
출처 데이터셋
uspto-grants-2013_03
특허 번호
US08404676B2

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