Hydrochloric Acid → cis-2-Pyrrolidin-1-yl-cyclohexylamine dihydrochloride

HRID 1950896

반응식

HRID 1950896 반응식
C(OC(=O)[NH:7][C@@H:8]1[CH2:13][CH2:12][CH2:11][CH2:10][C@@H:9]1[N:14]1[CH2:18][CH2:17][CH2:16][CH2:15]1)(C)(C)C.[ClH:20]>O1CCOCC1>[ClH:20].[ClH:20].[N:14]1([C@H:9]2[CH2:10][CH2:11][CH2:12][CH2:13][C@H:8]2[NH2:7])[CH2:15][CH2:16][CH2:17][CH2:18]1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 66680888cis-(2-Pyrrolidin-1-yl-cyclohexyl)-carbamic acid tert-butyl ester

생성물 1

HCID 66680564cis-2-Pyrrolidin-1-yl-cyclohexylamine dihydrochloride수율 85%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매2회

실험 절차

cis-(2-Pyrrolidin-1-yl-cyclohexyl)-carbamic acid tert-butyl ester (1.8 g, 6.7 mmol) was dissolved in dioxane. 4H HCl in dioxane (17 mL, 67 mmol) were added and the reaction mixture was stirred at room temperature overnight. The solvent was evaporated off. The residue was crystallized with ethanol and yielded cis-2-pyrrolidin-1-yl-cyclohexylamine dihydrochloride as a white solid (1.37 g, 85%), MS: m/e=169.2 [(M+H)+].

후처리

  1. customThe solvent was evaporated off
  2. customThe residue was crystallized with ethanol

출처 및 근거

ORD 기록
ord-826d66ca1440479b9ffe73346e50cb50
출처 데이터셋
uspto-grants-2013_03
특허 번호
US08404673B2

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