Phosphorus tribromide → 6-(Bromomethyl)pyrido[3,2-d]pyrimidine-2,4-diamine

HRID 1952780노트

반응식

HRID 1952780 반응식
[NH2:1][C:2]1[N:3]=[C:4]([NH2:14])[C:5]2[N:11]=[C:10]([CH2:12]O)[CH:9]=[CH:8][C:6]=2[N:7]=1.P(Br)(Br)[Br:16]>C1COCC1>[NH2:1][C:2]1[N:3]=[C:4]([NH2:14])[C:5]2[N:11]=[C:10]([CH2:12][Br:16])[CH:9]=[CH:8][C:6]=2[N:7]=1

참가 물질

4

반응물 2

HCID 24614Phosphorus tribromideHCID 13345225(2,4-Diaminopyrido[3,2-d]pyrimidin-6-yl)methanol

생성물 1

HCID 133452266-(Bromomethyl)pyrido[3,2-d]pyrimidine-2,4-diamine

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

A suspension of 0.72 g (3.77 mmol) of 6 in 12 mL dry THF was stirred for 8 hours with 1 mL of phosphorus tribromide. The precipitated solid was filtered, washed with cold 50% THF-Ether, and dried to give 7. Because of the instability, this compound was not purified further. The 1HNMR showed that the majority of the solid was the desired compound.

후처리

  1. filtrationThe precipitated solid was filtered
  2. washwashed with cold 50% THF-Ether
  3. customdried
  4. customto give 7
  5. customBecause of the instability, this compound was not purified further

출처 및 근거

ORD 기록
ord-88aeee078fc04165a1649980b2d8b6d0
출처 데이터셋
uspto-grants-2000_09
특허 번호
US06114339

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