Hydrochloric Acid → 5-Methylfuran-3-carboxylic acid
반응식
[CH3:1][C:2]1[O:6][CH:5]=[C:4]([C:7]([O:9]CC)=[O:8])[CH:3]=1.[OH-].[K+].Cl>O>[CH3:1][C:2]1[O:6][CH:5]=[C:4]([C:7]([OH:9])=[O:8])[CH:3]=1참가 물질
5
반응 조건
- 온도
- 10 °C
실험 절차
A mixture of 31.7 g (206 mmol) of ethyl 5-methylfuran-3-carboxylate, 40 ml of 45% strength potassium hydroxide and 100 ml of water was refluxed for 4 h, then cooled to 10° C. and acidified to pH 1 with 15% strength hydrochloric acid. The resulting mixture was left at this temperature for 2 h, and the precipitate was filtered off and dried to constant weight at 45-50° C., resulting in 23.7 g (188 mmol, 91%) of 5-methylfuran-3-carboxylic acid.
후처리
- temperaturewas refluxed for 4 h
- filtrationthe precipitate was filtered off
- customdried to constant weight at 45-50° C.
출처 및 근거
- ORD 기록
- ord-7840415ec1db4da8883176945e9f6a36
- 출처 데이터셋
- uspto-grants-2000_09
- 특허 번호
- US06114358
반응 노트
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