Hydrochloric Acid → 2-(Hydroxyimino)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one

HRID 1952968노트

반응식

HRID 1952968 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][C:11]=1[O:12][CH3:13])[C:8](=[O:14])[CH2:7][CH2:6]2.[N:15](OCCC(C)C)=[O:16].Cl>C(O)C>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][C:11]=1[O:12][CH3:13])[C:8](=[O:14])[C:7](=[N:15][OH:16])[CH2:6]2

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 8053Isoamyl NitriteHCID 750185,6-Dimethoxy-1-indanone

생성물 1

HCID 67540042-(Hydroxyimino)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

5,6-Dimethoxy-1-indanone (0.078 moles, 15 g) is dissolved in absolute ethanol (550 ml), thermostated at 50° C., and added with isoamyl nitrite (0.086 moles, 11.9 ml) and conc. HCl (11.9 ml). After a few minutes the product precipitates. The reaction is kept at 50° C. for further 3 hours, then cooled at r.t. and the solid is filtered washing with absolute ethanol (50 ml) and ethyl ether (100 ml). The product is dried in oven under vacuum at r.t. Yield: 16.3 g (94.4%)

후처리

  1. customAfter a few minutes the product precipitates
  2. filtrationthe solid is filtered
  3. washwashing with absolute ethanol (50 ml) and ethyl ether (100 ml)
  4. customThe product is dried in oven under vacuum at r.t

출처 및 근거

ORD 기록
ord-d936209124fc4f798932fc5b440e1bda
출처 데이터셋
uspto-grants-2000_09
특허 번호
US06114391

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