Lithium hydroxide, monohydrate → HCID 178524764, 화합물
반응식
O[Li].O.[OH:4][C:5]1[C:10]([C:11]([O:13]C)=[O:12])=[CH:9][N:8]=[CH:7][N:6]=1>O.O1CCCC1>[OH:4][C:5]1[C:10]([C:11]([OH:13])=[O:12])=[CH:9][N:8]=[CH:7][N:6]=1참가 물질
4
실험 절차
The moist sodium salt of methyl 4-hydroxypyrimidine-5-carboxylate obtained as in Example 2a) was taken up in water/tetrahydrofuran=1:1, and 1.0 eq of LiOH.H2O was added. Following hydrolysis of the ester over 3.5 hours at 0° C. and 2 hours at room temperature, most of the tetrahydrofuran was evaporated and, at 0° C., a pH of 3 was adjusted using eq. HCl solution. After about 45 minutes at 0° C., the title product was filtered off. Drying gave the acid in a yield of 3.55 g (78%).
후처리
- additionwas added
- custom2 hours at room temperature, most of the tetrahydrofuran was evaporated and, at 0° C.
- filtrationthe title product was filtered off
- customDrying
- customgave the acid in a yield of 3.55 g (78%)
출처 및 근거
- ORD 기록
- ord-bf7b8571eb4f4372a70f6bb8fc3b029e
- 출처 데이터셋
- uspto-grants-2000_09
- 특허 번호
- US06114527
반응 노트
불러오는 중…