Dimethylformamide → 4-(4-Fluorophenoxy)benzenesulphonyl chloride

HRID 1953229노트

반응식

HRID 1953229 반응식
[F:1][C:2]1[CH:18]=[CH:17][C:5]([O:6][C:7]2[CH:12]=[CH:11][C:10]([S:13](O)(=[O:15])=[O:14])=[CH:9][CH:8]=2)=[CH:4][CH:3]=1.[Na].S(Cl)([Cl:22])=O.CN(C)C=O>C1(C)C=CC=CC=1>[F:1][C:2]1[CH:18]=[CH:17][C:5]([O:6][C:7]2[CH:12]=[CH:11][C:10]([S:13]([Cl:22])(=[O:15])=[O:14])=[CH:9][CH:8]=2)=[CH:4][CH:3]=1

참가 물질

6

반응물 4

HCID 6228DimethylformamideHCID 24386Thionyl ChlorideHCID 5360545SodiumHCID 110225964-(4-fluorophenoxy)benzenesulfonic Acid

생성물 1

HCID 27827574-(4-Fluorophenoxy)benzenesulphonyl chloride

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

To a slurry of 15.0 g (0.052 mol) of 4-(4-fluorophenoxy)benzenesulfonic acid□, sodium salt, in 150 mL of dry toluene was added 11.3 mL (0.155 mol, 3 equivalents) of thionyl chloride and 0.04 mL (0.5 mmol, 0.01 equivalents) of dimethylformamide. The resulting mixture was stirred at room temperature for 48 hours, filtered through diatomaceous earth, and concentrated under reduced pressure to 40 mL. This solution was used without further purification to prepare 1-[4-(4-fluorophenoxy)benzenesulfonylamino] cyclopentanecarboxylic acid benzyl ester.

후처리

  1. filtrationfiltered through diatomaceous earth
  2. concentrationconcentrated under reduced pressure to 40 mL
  3. customThis solution was used without further purification
  4. customto prepare 1-[4-(4-fluorophenoxy)benzenesulfonylamino] cyclopentanecarboxylic acid benzyl ester

출처 및 근거

ORD 기록
ord-e2518a412ec54e5b887d14cd5fbbcffd
출처 데이터셋
uspto-grants-2000_09
특허 번호
US06114568

반응 노트

불러오는 중…