Phosphorus pentachloride → 2-Chloro-1-methyl-5-nitro-1H-benzimidazole

HRID 1953261노트

반응식

HRID 1953261 반응식
P(Cl)(Cl)(Cl)(Cl)[Cl:2].[N+:7]([C:10]1[CH:20]=[CH:19][C:13]2[N:14]([CH3:18])[C:15](=O)[NH:16][C:12]=2[CH:11]=1)([O-:9])=[O:8]>P(Cl)(Cl)(Cl)=O>[N+:7]([C:10]1[CH:20]=[CH:19][C:13]2[N:14]([CH3:18])[C:15]([Cl:2])=[N:16][C:12]=2[CH:11]=1)([O-:9])=[O:8]

참가 물질

4

반응물 2

HCID 24819Phosphorus pentachlorideHCID 6063051-Methyl-5-nitro-1,3-dihydro-2H-benzimidazol-2-one

생성물 1

HCID 108223912-Chloro-1-methyl-5-nitro-1H-benzimidazole

시약·촉매·용매 1

HCID 24813Phosphorus oxychloride용매

반응 조건

온도
125 °C

실험 절차

2.1 g (0.01 mol) of phosphorus pentachloride are dissolved in 2.5 ml phosphorus oxychloride and after the addition of 1.9 g (0.01 mol) of 5-nitro-1-methyl-benzimidazol-2-one the mixture is stirred for two hours at 125° C. The solvent is evaporated off, the residue is poured onto ice water and neutralised with ammonia. The precipitate formed is suction filtered and dried.

후처리

  1. customThe solvent is evaporated off
  2. additionthe residue is poured onto ice water and neutralised with ammonia
  3. customThe precipitate formed
  4. filtrationfiltered
  5. customdried

출처 및 근거

ORD 기록
ord-34226644c38e457ebf81005291fb39db
출처 데이터셋
uspto-grants-2000_09
특허 번호
US06114532

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