Lithium Bromide → (4-(Bromomethyl)phenoxy)(tert-butyl)dimethylsilane

HRID 1953383노트

반응식

HRID 1953383 반응식
FC(F)(F)C(O[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][Si:14]([C:17]([CH3:20])([CH3:19])[CH3:18])([CH3:16])[CH3:15])=[CH:9][CH:8]=1)=O.[Br-:23].[Li+]>C1COCC1.C(#N)C>[Si:14]([O:13][C:10]1[CH:11]=[CH:12][C:7]([CH2:6][Br:23])=[CH:8][CH:9]=1)([C:17]([CH3:20])([CH3:19])[CH3:18])([CH3:16])[CH3:15]

참가 물질

5

반응물 2

HCID 82050Lithium BromideHCID 99970054-{(t-Butyldimethylsilyl)oxy}benzyl trifluoroacetate

생성물 1

HCID 10380115(4-(Bromomethyl)phenoxy)(tert-butyl)dimethylsilane수율 88%

시약·촉매·용매 2

HCID 6342Acetonitrile용매HCID 8028Tetrahydrofuran용매

실험 절차

The benzyl trifluoroacetate 8 (17.9 g) was dissolved in dry THF, and dry lithium bromide (5.06 g) was added with stirring. The mixture was refluxed overnight, cooled, diluted with acetonitrile, and extracted three times with hexane. The hexane layers were combined, dried, filtered, and concentrated, thereby leaving the product 10 as a white oil in 88% yield.

후처리

  1. temperatureThe mixture was refluxed overnight
  2. temperaturecooled
  3. extractionextracted three times with hexane
  4. customdried
  5. filtrationfiltered
  6. concentrationconcentrated

출처 및 근거

ORD 기록
ord-caea78892fa840b9b949dda17bcf4585
출처 데이터셋
uspto-grants-2000_09
특허 번호
US06117845

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