Sodium Bicarbonate → 2-[3-(3-Aminophenyl)phenylamino]-3-nitropyridine

HRID 1953410노트

반응식

HRID 1953410 반응식
C([NH:4][C:5]1[CH:6]=[C:7]([C:11]2[CH:12]=[C:13]([NH:17][C:18]3[C:23]([N+:24]([O-:26])=[O:25])=[CH:22][CH:21]=[CH:20][N:19]=3)[CH:14]=[CH:15][CH:16]=2)[CH:8]=[CH:9][CH:10]=1)(=O)C.C(=O)(O)[O-].[Na+]>Cl>[NH2:4][C:5]1[CH:6]=[C:7]([C:11]2[CH:12]=[C:13]([NH:17][C:18]3[C:23]([N+:24]([O-:26])=[O:25])=[CH:22][CH:21]=[CH:20][N:19]=3)[CH:14]=[CH:15][CH:16]=2)[CH:8]=[CH:9][CH:10]=1

참가 물질

4

반응물 2

HCID 516892Sodium BicarbonateHCID 227244202-[3-(3-Acetamidophenyl)phenylamino]-3-nitropyridine

생성물 1

HCID 232981392-[3-(3-Aminophenyl)phenylamino]-3-nitropyridine수율 108.4%

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

A solution of 2-[3-(3-acetamidophenyl)phenylamino]-3-nitropyridine (10 g) in 3N hydrochloric acid (100 ml) was refluxed for 2 hours. The cold reaction was adjusted to pH 8 with saturated sodium bicarbonate solution and precipitated reddish crystals were collected, washed with water and dried to give 2-[3-(3-aminophenyl)phenylamino]-3-nitropyridine (9.53 g).

후처리

  1. customThe cold reaction
  2. customprecipitated reddish crystals
  3. customwere collected
  4. washwashed with water
  5. customdried

출처 및 근거

ORD 기록
ord-81168846e7234685b30b56206904f71f
출처 데이터셋
uspto-grants-2000_09
특허 번호
US06117875

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