Methyl iodide → methyl (2RS,3S)-3-amino-2-hydroxyheptanoate

HRID 1953441노트

반응식

[NH2:1][C@@H:2]([CH2:15][CH2:16][CH2:17][CH3:18])[CH:3]([OH:14])[C:4]([O:6][CH2:7]C1C=CC=CC=1)=[O:5].C(Br)C1C=CC=CC=1.CI>>[NH2:1][C@@H:2]([CH2:15][CH2:16][CH2:17][CH3:18])[CH:3]([OH:14])[C:4]([O:6][CH3:7])=[O:5]

참가 물질

반응물 3

HCID 6328Methyl iodide

HCID 7498Benzyl Bromide

HCID 56995658phenylmethyl (2RS,3S)-3-amino-2-hydroxyheptanoate

생성물 1

HCID 54272153methyl (2RS,3S)-3-amino-2-hydroxyheptanoate수율 91%

실험 절차

The same reaction procedure for synthesizing of phenylmethyl (2RS,3S)-3-amino-2-hydroxyheptanoate as in Reference Example 17 was repeated except that benzyl bromide used in Reference Example 17 was replaced by 579 mg of methyl iodide, whereby 683 mg of the captioned methyl (2RS,3S)-3-amino-2-hydroxyheptanoate was obtained in a yield of 91%.

후처리

customThe same reaction procedure

출처 및 근거

ORD 기록: ord-c5f9c186745040cf8ede17d73f1edc76
출처 데이터셋: uspto-grants-2000_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06117870

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