Cuminaldehyde → HCID 3583733, 화합물

반응식

[NH2:1][CH2:2][CH2:3][C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[NH:6][CH:5]=1.[CH:13]([C:16]1[CH:23]=[CH:22][C:19]([CH:20]=O)=[CH:18][CH:17]=1)([CH3:15])[CH3:14].C(O)(C(F)(F)F)=O>>[CH:13]([C:16]1[CH:23]=[CH:22][C:19]([CH:20]2[C:5]3[NH:6][C:7]4[C:12](=[CH:11][CH:10]=[CH:9][CH:8]=4)[C:4]=3[CH2:3][CH2:2][NH:1]2)=[CH:18][CH:17]=1)([CH3:15])[CH3:14]

참가 물질

반응물 3

HCID 326Cuminaldehyde

HCID 1150Tryptamine

HCID 6422Trifluoroacetic acid

생성물 1

HCID 3583733HCID 3583733, 화합물수율 67%

실험 절차

This product was prepared using the same procedure as for Intermediate 1 with tryptamine (5.0 g, 31.2 mmol), 4-isopropylbenzaldehyde (5.08 g, 1.1 equiv.) and TFA (4.8 mL, 2 equiv.) to give the title compound (5.9 g, 67%) as white crystals after recrystallization from iPr2O.

후처리

customThis product was prepared

출처 및 근거

ORD 기록: ord-86179a8a880446b1923c94b03d8c217e
출처 데이터셋: uspto-grants-2000_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06117881

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