Dimethyl Sulfoxide → 2-Chloro-3-nitrobenzaldehyde

HRID 1953520

반응식

HRID 1953520 반응식
Br[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([N+:9]([O-:11])=[O:10])[C:4]=1[Cl:12].CCN(CC)CC.CS(C)=[O:22]>C1(C)C=CC(S([O-])(=O)=O)=CC=1.[Ag+]>[Cl:12][C:4]1[C:5]([N+:9]([O-:11])=[O:10])=[CH:6][CH:7]=[CH:8][C:3]=1[CH:2]=[O:22]

참가 물질

5

반응물 3

HCID 679Dimethyl SulfoxideHCID 8471TriethylamineHCID 183630451-(Bromomethyl)-2-chloro-3-nitrobenzene

생성물 1

HCID 126677132-Chloro-3-nitrobenzaldehyde수율 20%

시약·촉매·용매 1

HCID 85606Benzenesulfonic acid, 4-methyl-, silver(1+) salt (1:1)촉매

실험 절차

2-Chloro-3-nitrobenzaldehyde (150 mg, 20%) was prepared by reaction of 1-bromomethyl-2-chloro-3-nitrobenzene (1.0 g, 3.9 mmol) with silver p-toluenesulfonate (1.94 g, 1.75 equiv.) in DMSO in the presence of Et3N (4 mL, 7 equiv.) at rt for 1 hour.

출처 및 근거

ORD 기록
ord-3d1f8fa0a4094acbbd9fb996f554ad01
출처 데이터셋
uspto-grants-2000_09
특허 번호
US06117881

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