홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Sulfuric acid magnesium salt (1:1) → Dimethyl N-(2,3-dimethoxy-7-nitroquinoxalin-5-ylmethyl)-beta-aminopropylphosphonate

HRID 1953783
노트
인쇄 미리보기

반응식

HRID 1953783 반응식
[NH2:1][CH2:2][C:3]1[CH:12]=[C:11]([N+:13]([O-:15])=[O:14])[CH:10]=[C:9]2[C:4]=1[N:5]=[C:6]([O:18][CH3:19])[C:7]([O:16][CH3:17])=[N:8]2.S([O-])([O-])(=O)=O.[Mg+2].O=[C:27]([CH3:35])[CH2:28][P:29](=[O:34])([O:32][CH3:33])[O:30][CH3:31].C([BH3-])#N.[Na+]>ClCCl.C(O)(=O)C.CO>[CH3:17][O:16][C:7]1[C:6]([O:18][CH3:19])=[N:5][C:4]2[C:9](=[CH:10][C:11]([N+:13]([O-:15])=[O:14])=[CH:12][C:3]=2[CH2:2][NH:1][CH:27]([CH3:35])[CH2:28][P:29](=[O:34])([O:32][CH3:33])[O:30][CH3:31])[N:8]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

8

반응물 4

HCID 24083Sulfuric acid magnesium salt (1:1)HCID 77872Dimethyl (2-oxopropyl)phosphonateHCID 5003444Sodium cyanoborohydrideHCID 179152965-Aminomethyl-2,3-dimethoxy-7-nitro-quinoxaline

생성물 1

HCID 23298051Dimethyl N-(2,3-dimethoxy-7-nitroquinoxalin-5-ylmethyl)-beta-aminopropylphosphonate

시약·촉매·용매 3

HCID 176
Acetic Acid
용매
HCID 887Methanol용매
HCID 6344Dichloromethane용매

실험 절차

200 mg (0.757 mmol) of 5-aminomethyl-7-nitro-2,3-dimethoxyquinoxaline, 547 mg (4.5 eq.) of magnesium sulfate and 163 mg (1.3 eq.) of dimethyl 2-oxopropylphosphonate are stirred at room temperature for 20 hours in 8 ml of dichloromethane. 4 ml of methanol, 0.095 ml of acetic acid and 52 mg (1.1 eq.) of sodium cyanoborohydride are then added and stirred for 4 hours. The reaction mixture is then filtered and the filtrate is extracted with water and brine. The organic phases are combined, dried over magnesium sulfate and evaporated. The title compound is obtained as a brown oil.

후처리

  1. filtrationThe reaction mixture is then filtered
  2. extractionthe filtrate is extracted with water and brine
  3. dry with materialdried over magnesium sulfate
  4. customevaporated

출처 및 근거

ORD 기록
ord-334cfcc977314de598a322b4776a869b
출처 데이터셋
uspto-grants-2000_09
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US06117873

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트