Diisopropylethylamine → Diethyl N-(2,3-dimethoxy-7-nitroquinoxalin-5-ylmethyl)-2-aminophenylphosphonate

HRID 1953784노트

반응식

HRID 1953784 반응식
Br[CH2:2][C:3]1[CH:12]=[C:11]([N+:13]([O-:15])=[O:14])[CH:10]=[C:9]2[C:4]=1[N:5]=[C:6]([O:18][CH3:19])[C:7]([O:16][CH3:17])=[N:8]2.[NH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=1[P:27](=[O:34])([O:31][CH2:32][CH3:33])[O:28][CH2:29][CH3:30].C(N(C(C)C)CC)(C)C>C(#N)C>[CH3:17][O:16][C:7]1[C:6]([O:18][CH3:19])=[N:5][C:4]2[C:9](=[CH:10][C:11]([N+:13]([O-:15])=[O:14])=[CH:12][C:3]=2[CH2:2][NH:20][C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=2[P:27](=[O:34])([O:28][CH2:29][CH3:30])[O:31][CH2:32][CH3:33])[N:8]=1

참가 물질

5

반응물 3

HCID 81531DiisopropylethylamineHCID 12482984Diethyl (2-aminophenyl)phosphonateHCID 232979835-Bromomethyl-7-nitro-2,3-dimethoxyquinoxaline

생성물 1

HCID 23297993Diethyl N-(2,3-dimethoxy-7-nitroquinoxalin-5-ylmethyl)-2-aminophenylphosphonate

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

190 mg (0.579 mmol) of 5-bromomethyl-7-nitro-2,3-dimethoxyquinoxaline, 159 mg (1.2 eq.) of diethyl 2-aminophenylphosphonate and 0.2 ml (2 eq.) of diisopropylethylamine are stirred at reflux for 20 hours in 8 ml of acetonitrile. The reaction mixture is evaporated and the residue is extracted with water and ethyl acetate. The combined organic phases are dried using brine and magnesium sulfate and evaporated. The title compound is obtained as a yellow solid.

후처리

  1. customThe reaction mixture is evaporated
  2. extractionthe residue is extracted with water and ethyl acetate
  3. customThe combined organic phases are dried
  4. customevaporated

출처 및 근거

ORD 기록
ord-5c1987d5ec6240529002594ae1d4839e
출처 데이터셋
uspto-grants-2000_09
특허 번호
US06117873

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