Benzoyl chloride → HCID 15615417, 화합물

HRID 1953805

반응식

HRID 1953805 반응식
[C:1](Cl)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Br.[Br:11][CH:12]1[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]1.C(N(CC)CC)C>C1COCC1>[C:1]([N:15]1[CH2:16][CH2:17][CH:12]([Br:11])[CH2:13][CH2:14]1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 7412Benzoyl chlorideHCID 8471TriethylamineHCID 27346764-Bromopiperidine Hydrobromide

생성물 1

HCID 15615417HCID 15615417, 화합물수율 102.9%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

Benzoyl chloride (1.41 g) was added to a solution of 4-bromopiperidine hydrobromide (2.45 g) in THF (30 ml) at 0° C., followed by triethylamine (2.2 g, 2.2 eq). The solution was stirred at room temperature for 1 h, and evaporated and. The residue was dissolved in dichloromethane (100 ml), washed with water, 1M HCl and saturated sodium bicarbonate, dried and evaporated to give the title compound as colourless oil (2.76 g, 100%).

후처리

  1. customevaporated
  2. dissolutionThe residue was dissolved in dichloromethane (100 ml)
  3. washwashed with water, 1M HCl and saturated sodium bicarbonate
  4. customdried
  5. customevaporated

출처 및 근거

ORD 기록
ord-5a3be90131314de5928df8f2e7b55486
출처 데이터셋
uspto-grants-2000_09
특허 번호
US06118001

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