Imidazole → 5-Amino-4-fluoro-2-(1-imidazolyl)nitrobenzene
반응식
[NH2:1][C:2]1[C:3]([F:12])=[CH:4][C:5](F)=[C:6]([N+:8]([O-:10])=[O:9])[CH:7]=1.[NH:13]1[CH:17]=[CH:16][N:15]=[CH:14]1.[H-].[Na+]>O>[NH2:1][C:2]1[C:3]([F:12])=[CH:4][C:5]([N:13]2[CH:17]=[CH:16][N:15]=[CH:14]2)=[C:6]([N+:8]([O-:10])=[O:9])[CH:7]=1참가 물질
5
실험 절차
12 g (0.068 mol) of 5-amino-2,4-difluoronitrobenzene were slowly added at 0° C. to a solution of 4.7 g of imidazole (0.069 mol) and 2.1 g of sodium hydride (80% in oil; 0.07 mol) and then stirred at this temperature for several hours. The mixture was then diluted with water and extracted several times with methylene chloride. The residue after drying and evaporation was recrystallized from isopropanol.
후처리
- extractionextracted several times with methylene chloride
- customThe residue after drying
- customevaporation
- customwas recrystallized from isopropanol
출처 및 근거
- ORD 기록
- ord-ae16d0c9eb5d41978167ef239ba9d959
- 출처 데이터셋
- uspto-grants-2000_09
- 특허 번호
- US06121265
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