Chloroacetamide → Diethyl 2-amino-6-[(2-amino-2-oxo-ethoxycarbamoyl)-methyl]-azulene-1,3-dicarboxylate

HRID 1954349노트

반응식

HRID 1954349 반응식
[Na].[NH2:2][C:3]1[C:12]([C:13]([O:15][CH2:16][CH3:17])=[O:14])=[C:11]2[C:5](=[CH:6][CH:7]=[C:8]([CH2:18][C:19](=[O:22])[NH:20][OH:21])[CH:9]=[CH:10]2)[C:4]=1[C:23]([O:25][CH2:26][CH3:27])=[O:24].Cl[CH2:29][C:30]([NH2:32])=[O:31]>>[NH2:2][C:3]1[C:12]([C:13]([O:15][CH2:16][CH3:17])=[O:14])=[C:11]2[C:5](=[CH:6][CH:7]=[C:8]([CH2:18][C:19](=[O:22])[NH:20][O:21][CH2:29][C:30]([NH2:32])=[O:31])[CH:9]=[CH:10]2)[C:4]=1[C:23]([O:25][CH2:26][CH3:27])=[O:24]

참가 물질

3

반응물 2

HCID 6580ChloroacetamideHCID 86755843Diethyl 2-amino-6-[(hydroxycarbamoyl)-methyl]-azulene-1,3-dicarboxylate sodium

생성물 1

HCID 54350698Diethyl 2-amino-6-[(2-amino-2-oxo-ethoxycarbamoyl)-methyl]-azulene-1,3-dicarboxylate수율 26%

실험 절차

In an analogous manner to that described in Example 1, from diethyl 2-amino-6-[(hydroxycarbamoyl)-methyl]-azulene-1,3-dicarboxylate sodium and 2-chloroacetamide the title compound of m.p. 208-210° C. is obtained in 26% yield.

출처 및 근거

ORD 기록
ord-8aad518eb4d142728a557f1c28518dc5
출처 데이터셋
uspto-grants-2000_09
특허 번호
US06121322

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