Sodium Hydroxide → 1-cyclohexyl-1-hydroxy-6-methoxy-3-phenyl-1H-indene-2-carboxylic acid

HRID 19545

반응식

HRID 19545 반응식
C([O:3][C:4]([C:6]1[C:7]([CH:24]2[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]2)([OH:23])[C:8]2[C:13]([C:14]=1[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=[CH:12][CH:11]=[C:10]([O:21][CH3:22])[CH:9]=2)=[O:5])C.[OH-].[Na+]>C1COCC1.C(O)C>[CH:24]1([C:7]2([OH:23])[C:8]3[C:13](=[CH:12][CH:11]=[C:10]([O:21][CH3:22])[CH:9]=3)[C:14]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)=[C:6]2[C:4]([OH:5])=[O:3])[CH2:25][CH2:26][CH2:27][CH2:28][CH2:29]1

참가 물질

5

반응물 2

HCID 14798Sodium HydroxideHCID 116397521-cyclohexyl-1-hydroxy-6-methoxy-3-phenyl-1H-indene-2-carboxylic acid ethyl ester

생성물 1

HCID 115886351-cyclohexyl-1-hydroxy-6-methoxy-3-phenyl-1H-indene-2-carboxylic acid수율 80.7%

시약·촉매·용매 2

HCID 702Ethanol용매HCID 8028Tetrahydrofuran용매

실험 절차

1-Cyclohexyl-1-hydroxy-6-methoxy-3-phenyl-1H-indene-2-carboxylic acid ethyl ester (20 mg, 0.051 mmol) prepared in Example 6 was dissolved in THF, and an excess amount of sodium hydroxide dissolved in aqueous ethanol was added thereto in such a way not to cause layer separation. The mixture was stirred for 24 hrs at RT, and the pH was adjusted to 3˜4 using 2N hydrochloric acid. The resulting mixture was extracted with ethyl acetate. The organic layer was separated, dried over anhydrous MgSO4 and concentrated under a reduced pressure, to obtain 15 mg of the titled compound (yield: 80%).

후처리

  1. additionwas added
  2. customlayer separation
  3. extractionThe resulting mixture was extracted with ethyl acetate
  4. customThe organic layer was separated
  5. dry with materialdried over anhydrous MgSO4
  6. concentrationconcentrated under a reduced pressure

출처 및 근거

ORD 기록
ord-1c003512fe3e4c9f94c490f9ac318324
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07745439B2

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