Hydrogen Bromide → 4'-Bromomethyl-4-decyloxybiphenyl

HRID 1955471

반응식

HRID 1955471 반응식
O[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:14]=[CH:13][C:12]([O:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25])=[CH:11][CH:10]=2)=[CH:5][CH:4]=1.[BrH:26]>>[Br:26][CH2:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:14]=[CH:13][C:12]([O:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25])=[CH:11][CH:10]=2)=[CH:5][CH:4]=1

참가 물질

3

반응물 2

HCID 260Hydrogen BromideHCID 190699634-Hydroxymethyl-4'-decyloxybiphenyl

생성물 1

HCID 190699574'-Bromomethyl-4-decyloxybiphenyl

반응 조건

온도
115 °C

실험 절차

To 0.81 g (2.51 mmol) of 4-hydroxymethyl-4'-decyloxybiphenyl was added 15 ml of an aqueous solution containing 47% HBr, and then heated at 115° C. for 3 hours. After completion of the reaction, the resultant mixture was extracted with ether and washed with water, which was further washed with an aqueous solution containing saturated NaHCO3 and washed again with water. The reaction product was concentrated and, then, separated by colomun chromatography, to thereby obtain 0.92 g of 4'-bromomethyl-4-decyloxybiphenyl.

후처리

  1. customAfter completion of the reaction
  2. extractionthe resultant mixture was extracted with ether
  3. washwashed with water, which
  4. washwas further washed with an aqueous solution
  5. additioncontaining saturated NaHCO3
  6. washwashed again with water
  7. concentrationThe reaction product was concentrated
  8. customseparated by colomun chromatography

출처 및 근거

ORD 기록
ord-004fe70502444dc09e8ead826065f7b8
출처 데이터셋
uspto-grants-1998_07
특허 번호
US05776365

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