Phosphorus trichloride → Dimethyl Quinoline-2,3-dicarboxylate

HRID 1955604노트

반응식

HRID 1955604 반응식
[N+:1]1([O-])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[C:3]([C:11]([O:13][CH3:14])=[O:12])[C:2]=1[C:15]([O:17][CH3:18])=[O:16].P(Cl)(Cl)Cl>C(Cl)(Cl)Cl>[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[C:3]([C:11]([O:13][CH3:14])=[O:12])[C:2]=1[C:15]([O:17][CH3:18])=[O:16]

참가 물질

4

반응물 2

HCID 24387Phosphorus trichlorideHCID 15366557HCID 15366557, 화합물

생성물 1

HCID 11010215Dimethyl Quinoline-2,3-dicarboxylate

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

A solution of N-oxide 3 (10 mM) and phosphorus trichloride (30 mM) in anhydrous chloroform (100 ml) was refluxed for 7 h. Solvent was removed under reduced pressure and the residue was partitioned between ethyl acetate and water. The organic layer was dried over sodium sulphate and then evaporated under reduced pressure. The residue was recrystallized from isopropanol to provide the title dimethyl quinoline-2,3-dicarboxylate 7 as an off white (or light yellow) powder.

후처리

  1. customSolvent was removed under reduced pressure
  2. customthe residue was partitioned between ethyl acetate and water
  3. dry with materialThe organic layer was dried over sodium sulphate
  4. customevaporated under reduced pressure
  5. customThe residue was recrystallized from isopropanol

출처 및 근거

ORD 기록
ord-4ee3d8d301824f80b57afcbb6894ed3d
출처 데이터셋
uspto-grants-1998_07
특허 번호
US05776935

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