6-Methoxy-1-Indanone → 1-(2-Methylpropionyl)-4-(6-methoxy-indan-1-yl)piperazine

HRID 1956155

반응식

HRID 1956155 반응식
[CH3:1][O:2][C:3]1[CH:11]=[C:10]2[C:6]([CH2:7][CH2:8][C:9]2=O)=[CH:5][CH:4]=1.[CH3:13][CH:14]([CH3:23])[C:15]([N:17]1[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]1)=[O:16].[BH4-].[Na+]>CC(C)[O-].[Ti+4].CC(C)[O-].CC(C)[O-].CC(C)[O-]>[CH3:13][CH:14]([CH3:23])[C:15]([N:17]1[CH2:22][CH2:21][N:20]([CH:9]2[C:10]3[C:6](=[CH:5][CH:4]=[C:3]([O:2][CH3:1])[CH:11]=3)[CH2:7][CH2:8]2)[CH2:19][CH2:18]1)=[O:16]

참가 물질

5

반응물 3

HCID 3340366-Methoxy-1-IndanoneHCID 27614092-Methyl-1-(piperazin-1-yl)propan-1-oneHCID 4311764Sodium borohydride

생성물 1

HCID 223753721-(2-Methylpropionyl)-4-(6-methoxy-indan-1-yl)piperazine

시약·촉매·용매 1

HCID 11026Titanium isopropoxide촉매

실험 절차

The title compound was prepared by the above procedure using 6-methoxy-1-indanone (3.2 g, 20 mmol), 1-(2-methylpropionyl)piperazine (3.0 g, 20 mmol), titanium(IV) isopropoxide (8 mL, 24 mmol) and sodium borohydride (2.7 g, 67 mmol) to give 2.2 g of product as the fumarate salt.

출처 및 근거

ORD 기록
ord-010d0fcb2a21446192f78da67184b117
출처 데이터셋
uspto-grants-1998_07
특허 번호
US05780470

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