Phosphorus oxychloride → Ethyl 4-chloro-7-ethoxy-1,8-naphthyridine-3-carboxylate

HRID 1956422노트

반응식

HRID 1956422 반응식
[CH2:1]([O:3][C:4]1[N:13]=[C:12]2[C:7]([C:8](O)=[C:9]([C:14]([O:16][CH2:17][CH3:18])=[O:15])[CH:10]=[N:11]2)=[CH:6][CH:5]=1)[CH3:2].P(Cl)(Cl)([Cl:22])=O>>[Cl:22][C:8]1[C:7]2[C:12](=[N:13][C:4]([O:3][CH2:1][CH3:2])=[CH:5][CH:6]=2)[N:11]=[CH:10][C:9]=1[C:14]([O:16][CH2:17][CH3:18])=[O:15]

참가 물질

3

반응물 2

HCID 24813Phosphorus oxychlorideHCID 178469695HCID 178469695, 화합물

생성물 1

HCID 19374322Ethyl 4-chloro-7-ethoxy-1,8-naphthyridine-3-carboxylate

실험 절차

In a similar manner to Example B1, ethyl 7-ethoxy-4-hydroxy-1,8-naphthyridine-3-carboxylate (8.8 g) and phosphorus oxychloride (50 ml) were heated at 80° C. for 25 minutes to give ethyl 4-chloro-7-ethoxy-1,8-naphthyridine-3-carboxylate, m.p. 72°-75° C.

출처 및 근거

ORD 기록
ord-9e89b7ae038d40b49fa8445753d44683
출처 데이터셋
uspto-grants-1998_07
특허 번호
US05780482

반응 노트

불러오는 중…