Ethylenediamine → Ethyl 2-fluorocyclopropanecarboxylate

HRID 1956830

반응식

HRID 1956830 반응식
Br[C:2]1([F:10])[CH2:4][CH:3]1[C:5]([O:7][CH2:8][CH3:9])=[O:6].NCCN>[C].[Pd].C(O)C>[F:10][CH:2]1[CH2:4][CH:3]1[C:5]([O:7][CH2:8][CH3:9])=[O:6]

참가 물질

5

반응물 2

HCID 3301EthylenediamineHCID 22371314Ethyl 2-bromo-2-fluoro-1-cyclopropanecarboxylate

생성물 1

HCID 10313150Ethyl 2-fluorocyclopropanecarboxylate수율 81%

시약·촉매·용매 2

HCID 178418390HCID 178418390, 화합물촉매HCID 702Ethanol용매

실험 절차

An internal glass tube was introduced into an autoclave and 211 mg of ethyl 2-bromo-2-fluoro-1-cyclopropanecarboxylate [obtained in accordance with the method of Bulletin of Faculty of Education, Wakayama University, 33, 33 (1984); cis:trans=0.8:1], 40 mg of 5% palladium-carbon (moisture content: 55% wet) and 8 ml of ethanol were fed thereinto. Then 90 mg of 1,2-diaminoethane was further added and the mixture was stirred at room temperature under an elevated hydrogen gas atmosphere (50 kgf/cm2) for 48 hours. After the completion of the reaction, the catalyst was filtered off. Then the reaction mixture containing the title compound was analyzed by gas chromatography. As a result, it was found out that the reaction conversion rate was 95%, the yield was 81% and the cis:trans ratio was 0.8:1.

후처리

  1. customobtained in accordance with the method of Bulletin of Faculty of Education, Wakayama University, 33, 33 (1984)
  2. customAfter the completion of the reaction
  3. filtrationthe catalyst was filtered off
  4. additionThen the reaction mixture containing the title compound

출처 및 근거

ORD 기록
ord-a23483b85c3847ae89ac28c8fbfe16b5
출처 데이터셋
uspto-grants-1998_07
특허 번호
US05780669

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