Water → 2-{N-[2-(4-chlorophenoxy)ethyl]-N-[3-(imidazol-1-yl)propyl]amino}ethanol

HRID 1956851노트

반응식

HRID 1956851 반응식
[H-].[Al+3].[Li+].[H-].[H-].[H-].[Cl:7][C:8]1[CH:30]=[CH:29][C:11]([O:12][CH2:13][CH2:14][N:15]([CH2:21][CH2:22][CH2:23][N:24]2[CH:28]=[CH:27][N:26]=[CH:25]2)[CH2:16][C:17](OC)=[O:18])=[CH:10][CH:9]=1.O.[OH-].[Na+]>C1COCC1>[Cl:7][C:8]1[CH:9]=[CH:10][C:11]([O:12][CH2:13][CH2:14][N:15]([CH2:16][CH2:17][OH:18])[CH2:21][CH2:22][CH2:23][N:24]2[CH:28]=[CH:27][N:26]=[CH:25]2)=[CH:29][CH:30]=1

참가 물질

6

반응물 4

HCID 962Water2회HCID 14798Sodium HydroxideHCID 18349617HCID 18349617, 화합물HCID 21226445Aluminium lithium hydride

생성물 1

HCID 183497742-{N-[2-(4-chlorophenoxy)ethyl]-N-[3-(imidazol-1-yl)propyl]amino}ethanol

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

Lithium aluminium hydride (0.23 g) was added to a solution of methyl N-[2-(4-chlorophenoxy)ethyl]-N-[3-(imidazol-1-yl)propyl]glycinate (1.30 g) in THF (30 ml). The mixture was boiled under reflux for 4 hours and then cooled. Water (1 ml) was added followed by 5M sodium hydroxide solution (2 ml) and then more water (2 ml). The mixture was filtered to remove the precipitate using a filtration aid. The filtrate was washed with water, dried and evaporated to give 2-{N-[2-(4-chlorophenoxy)ethyl]-N-[3-(imidazol-1-yl)propyl]amino}ethanol as an oil.

후처리

  1. temperatureunder reflux for 4 hours
  2. temperaturecooled
  3. filtrationThe mixture was filtered
  4. customto remove the precipitate
  5. washThe filtrate was washed with water
  6. customdried
  7. customevaporated

출처 및 근거

ORD 기록
ord-c27cdf32150747e98beec4e26df666c8
출처 데이터셋
uspto-grants-1998_07
특허 번호
US05780642

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