Water → Ergosterol, acetate

HRID 1957479노트

반응식

HRID 1957479 반응식
[CH3:1][C@@H:2]([C@@H:10]1[C@@:14]2([CH3:29])[CH2:15][CH2:16][C@@H:17]3[C@@:22]4([CH3:28])[CH2:23][CH2:24][C@H:25]([OH:27])[CH2:26][C:21]4=[CH:20][CH:19]=[C:18]3[C@@H:13]2[CH2:12][CH2:11]1)/[CH:3]=[CH:4]/[C@@H:5]([CH:7]([CH3:9])[CH3:8])[CH3:6].[C:30](OC(=O)C)(=[O:32])[CH3:31].O>N1C=CC=CC=1>[C:30]([O:27][C@H:25]1[CH2:24][CH2:23][C@@:22]2([CH3:28])[C:21](=[CH:20][CH:19]=[C:18]3[C@@H:17]2[CH2:16][CH2:15][C@@:14]2([CH3:29])[C@H:13]3[CH2:12][CH2:11][C@@H:10]2[C@H:2]([CH3:1])/[CH:3]=[CH:4]/[C@H:5]([CH3:6])[CH:7]([CH3:8])[CH3:9])[CH2:26]1)(=[O:32])[CH3:31]

참가 물질

5

반응물 3

HCID 962WaterHCID 7918Acetic AnhydrideHCID 444679Ergosterol

생성물 1

HCID 6436903Ergosterol, acetate수율 74%

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

To a solution of 50 gm (0.13 mol) of ergosterol (1) in 300 ml of anhydrous pyridine was added 33.3 ml (0.35 mol) of acetic anhydride. The mixture was stirred at room temperature overnight and then 600 ml of water was added. The precipitate was filtered and washed three times with 200 ml portions of acetonitrile and then air dried to yield 42.0 g (74%) of (2).

후처리

  1. filtrationThe precipitate was filtered
  2. washwashed three times with 200 ml portions of acetonitrile
  3. customair dried

출처 및 근거

ORD 기록
ord-ed15255e5d73475f811310c9f5b9ee02
출처 데이터셋
uspto-grants-1998_07
특허 번호
US05786348

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